Ca' Pisani was the first design hotel to be built in Venice. It offers an alternative to the classic Venetian hotel and is often frequented by leading figures of the arts. The hotel's exterior boasts a beautiful façade dating back to the fifteenth-century: a striking contrast to its eclectic interiors.

The palazzo itself is a fine example of a late thirteenth-century Venetian building of the nobility. In the late sixteenth century, the architect Roberto Canovaro renovated the palazzo whilst retaining its original character and turned it into a 29-bedroom hotel.

The style is very reminiscent of the nineteen thirties and forties with its Futurist figurative/geometric patterns, although it also features many contemporary details that give a modern-day feel: starlights or wrought iron, drops of silver or deep red hues, bamboo, marble and walnut wood.